Dr. James Madara, CEO of the American Medical Association, the largest organization of physicians and medical students with over 290,000 members, founded in 1847, describes the organization’s strategy and mission in patient care as a powerful ally to physicians, including R&D, their weekly Journal (JAMA), the largest circulating medical journal, and their innovation ecosystem. He talks about lessons learned during the pandemic, the importance of person-to-person interactions and telemedicine, and innovations and the future of medicine including insights on home health care. Finally, Dr. Madara reveals shocking statistics in the healthcare industry and burdensome obstacles impeding the provision of quality care and how they are advocating to change things and lower medical costs.