Jeffrey Balser, MD, President and CEO of Vanderbilt University Medical Center gives a cross-industry Ph.D. on building a phenomenal culture of over 40,000 employees and a story of huge growth and transformation, including the melding of “white coats and blue suits” and the development of special programs and unique practices to elevate all. Dr. Balser then explains why his background in engineering has been one of the keys to his success in problem-solving and managing a healthcare enterprise and a transferrable lesson he learned from his father-in-law in relentless pursuit of improvement. Next, Dr. Balser talks about how his leadership teams effectively use health information technology as a national leader to provide better healthcare. Finally, he shares what CEOs need to know about healthcare and what they need to do to truly open the gateway to transformation.